膳食铁摄入与妊娠期糖尿病的相关性研究

Correlation study on dietary iron intake and gestational diabetes mellitus

目的：探索膳食铁摄入与妊娠期糖尿病（GDM）的相关性,为GDM的防治提供参考。方法：在产检孕妇中,根据75 g糖耐量试验（OGTT）筛选出GDM患者108例为GDM组,随机选择糖耐量正常孕妇108例作为对照组进行病例对照研究。通过问卷调查。膳食调查和铁负荷水平检测,比较两组孕妇膳食铁摄入量和铁负荷指标的差异,并采用多因素Logistic回归分析计算GDM与高膳食铁摄入的OR值。结果：GDM组孕妇膳食铁摄入量显著高于对照组（P 〈 0.01）;GDM组血清铁蛋白水平为（84.64 ± 68.19）。滋g/L,与对照组（57.87 ± 55.77）。滋g/L比较,差异有统计学意义（P = 0.002）;高膳食铁摄入与GDM患病风险的OR值为1.037（95%可信区间为1.007~1.069）。结论：高水平膳食铁摄入与GDM的患病风险存在正相关。

Objective：To explore the correlation between dietary iron intake and gestational diabetes mellitus（GDM）, and provide a reference for the prevention of GDM. Methods：Totally 108 cases of GDM in prenatal women were selected according to OGTT （75 g glucose tolerance test）as GDM group, randomly selected 108 cases of pregnant women with normal glucose tolerance as the control group. Case-control analysis was carried out between the two groups. Through questionnaire survey, dietary survey and detection of iron overload level, the dietary iron intake and iron overload index were compared between the two groups. The OR values between GDM and its risk factors were analyzed by using multi-factor regression analysis. Results：The dietary iron intake in GDM was significantly higher than that in the control group（P 〈 0.01）. The mean serum ferritin in GDM was （84.64 ± 68.19）。滋g/L, which was higher than the value of normal group（57.87 ± 55.77）。滋g/L（P = 0.002）. The OR value of high dietary iron intake and risk of GDM was 1.037（95% confidence interval was 1.007~1.069）. Conclusion：The high level of dietary iron intake is positively correlated with GDM.