2011年住院患者抗菌药物使用及耐药情况分析

Analysis of patients with antimicrobial drug use and drug resistance in 2011

目的通过对2011年住院患者抗菌药物使用及耐药情况的分析,以期提高对抗菌药物的合理使用水平。方法统计2011年住院患者抗菌药物使用的相关数据,使用限定日剂量值(DDD值)分析方法,并结合抗菌药物耐药情况进行分析。结果我院的微生物样本送检率较低,抗菌药物选用未严格按照药敏结果。革兰氏阳性菌对万古霉素、利奈唑胺、呋喃妥因、复方新诺明的耐药性均小于30%,其他均高于65%。亚胺培南、美罗培南对铜绿假单胞菌的耐药率分别为37.8%和43.5%。两个碳青霉烯类鲍曼不动杆菌的耐药率分别为66.7%和72.3%,高于平均水平。结论我院须加强抗菌药物使用的管理,进一步提高抗菌药物分级管理水平,减缓细菌耐药性的发生。

Objective To improve the rational use level of antimicrobial agents through analysis of antimicrobial agents application and drug resistance of the patients in our hospital in 2011 .Methods The patients′antimicrobial agents application statistics were analyzed by using defined daily dose（DDD） and drug resistance was analyzed accordingly .Results The submission of microbiologi-cal testing sample in our hospital was low ,and the selection of antibiotics was not in accordance with susceptibility results .Resist-ance rates of Gram-positive bacteria to vancomycin ,linezolid ,furan ,cotrimoxazole were less than 30% ,and the others were higher than 65% .Resistance rates of pseudomonas aeruginosa to imipenem and meropenem were 37 .8% and 43 .5% .Resistance rates of Acinetobacter baumannii to the two carbapenem were 66 .7% and 72 .3% .Conclusion We must strengthen the management of an-tibiotics usage to further improve the antibacterial drug classification management level and slow down the occurrence of antibacte-rial resistance .