安心颗粒联合替罗非班对急性心肌梗死PCI术后患者临床疗效的研究

Effect of Anxin granules combined with tirofiba on patients with acute myocardial infarction after elective percutaneous coronary intervention

探讨安心颗粒联合GPⅡb/Ⅲa受体抑制剂替罗非班对急性心肌梗死(AMI)介入治疗患者的临床疗效。采用随机对照的临床试验方法,将120例病例来自广西中医药大学第一附属医院心血管科住院AMI患者,分为治疗组和对照组。2组患者PCI术前30 min均给予盐酸替罗非班,治疗组在对照组用药基础上,PCI术前和术后均给予安心颗粒。于术后6 h检测组织因子、血管性假血友病因子,术后4周观察患者中医证候积分和出血并发症的发生情况。结果显示,术后6 h,治疗组患者组织因子、血管性假血友病因子均显著低于对照组(P<0.01),治疗组患者术后90 min的心肌缺血状态改善程度较对照组有统计学差异。术后4周治疗组患者的中医临床证候学表现尤其是自汗乏力症状的改善更为显著(P<0.05),2组病人均未发生出血并发症和血小板减少症。研究表明安心颗粒联合替罗非班可显著提高急性心肌梗死介入治疗患者的临床疗效,改善其内皮功能,并且没有增加出血事件的发生。

To investigate the influence of Anxin granules combined with tirofiban on acute myocardial infarction （AMI） Patients after elective percutaneous coronary intervention （PCI）. One hundred and twenty AMI patients were randomly divided into treatment group and control group. The patients in the two groups were all given Tirofihan 30rains before PCI . The treatment group was added Anxin granules 30 mins before and after PCI. Tissue factor （TF） and yon willebrand factor （vWF） were tested at 6 hours after opera- tion. Syndromatology alteration of traditional Chinese medicine （TCM） and bleeding complications were observed at 4 weeks after oper- ation. Both TF and vWF at 6 hours after operation of the treatment group was lower than the control group significantly（ P 〈 0.01 ） , while the condition of myocardial ischemia at 90 mins after operation of the treatment group was better than control group with signifi- cance. The syndromatology alteration of TCM especially spontaneous perspiration and hypodynamia of the treatment group were im- proved significantly compared to control group 4 weeks after operation. All patients in both groups had no bleeding complications and thrombopenia. The study suggests that Anxin granules combined with tirofiba can improve the clinical efficacy and the endothelial function of AMI patients after PCI with no increase in bleeding events.