鲍曼不动杆菌毒力因子研究进展

Research Progress on Virulence Factors of Acinetobacter baumannii

鲍曼不动杆菌(Acinetobacter baumannii)是一种广泛分布于人类生活环境中的重要的条件致病菌,由于具有较强的抗药性,一直是生物医学领域中的研究热点。相对于抗药性的研究,对于毒力因子的了解就知之甚少。鲍曼不动杆菌入侵宿主后,可以在宿主体内长期存活,同时引起宿主细胞的严重损害,因此其毒力因子可能在入侵、增殖、杀伤过程中发挥重要作用。作者综述了近几年国内外关于鲍曼不动杆菌主要毒力因子的研究进展,以便于研究人员进一步了解鲍曼不动杆菌的致病机制,同时为治疗疾病和筛选药物提供新思路。

Acinetobacter baurnannii is an important condition opportunistic pathogen widely distributing in human living en vironment. Because of its strong drug-resistant character, it has always been a hot topic in the biomedical research field. How ever, little knowledge of its virulence factors is known comparing to the drug-resistance research. Acinetobacter baumannii can survive for a long time in host and cause serious damage to host cells after invading the host, so virulence factors might play an important role during the invasion, proliferation and injure process. Here, we summarized the advanced researches and pro- gresses on virulence factors of Acinetobacter baumannii for benefiting future study of its pathogenic mechanisms, providing new ideas for the potential treatment and screening drugs of diseases caused by Acinetobacter baumannii.