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MicroRNA-22在乳腺癌中的作用及机制 被引量：2

The role of microRNA-22 in breast cancer
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摘要 MicroRNA （miRNA）为非编码的单链小RNA分子,具有高度保守性、时序性和组织特异性.MicroRNA-22（miR-22）参与了骨骼代谢、心肌细胞成熟与肥大、胚胎干细胞的分化等生理病理过程.在乳腺癌中,miR-22则具有抑癌基因与癌基因的双重功能.miRNA-22有可能作为乳腺癌诊断和预后的指标,也可作为靶点为乳腺癌患者提供新的治疗策略. MicroRNAs（miRNAs） are known as small,non-coding,single stranded RNAs.miRNAs are highly conserved,temporal and tissue specific.MicroRNA-22 （miR-22） participates in a wealth of physiological and pathological processes,such as bone metabolism,cardiomyocyte maturation and hypertrophy,differentiation of embryonic stem cells,as well as tumor formation and progression.miR-22 can act not only as a tumor suppressor,but also as an oncogene in breast cancer.miR-22 may be used as a novel biological marker for the diagnosis and prognosis estimation of breast cancer.In addition,it also possible to develop treatment strategies by targeting miR-22.
作者 徐小丽 吴昌平 蒋敬庭
机构地区 江苏省苏州大学附属第三医院肿瘤生物诊疗中心
出处 《国际免疫学杂志》 CAS 2014年第2期87-90,共4页 International Journal of Immunology
基金 基金项目：国家自然科学基金（81171653,30972703） 江苏省自然科学基金（BK2011246,BK2011247） 常州市社会发展计划基金（CJ20112020,CZ20110024,CS20102020）
关键词 MicroRNA-22 乳腺癌 抑癌基因 癌基因 MicroRNA-22 Breast cancer Tumor suppressor Oncogene
分类号 R737.9 [医药卫生—肿瘤]
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参考文献34

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二级参考文献26

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国际免疫学杂志
2014年 第2期

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