肿瘤相关巨噬细胞在乳腺癌中的研究进展

Study advances in tumor-associated macrophages in breast cancer

肿瘤相关巨噬细胞（TAMs）能促进恶性肿瘤的血管生成、组织重建及减弱机体对肿瘤的免疫反应.在动物模型中特定类型的巨噬细胞能促进肿瘤转移,而临床研究发现TAMs与肿瘤不良预后相关.巨噬细胞具有多种表型状态.肿瘤微环境影响TAMs后使其部分变为非正常激活状态,即M2型巨噬细胞,另一部分仍为创伤愈合调节状态,即M1型巨噬细胞.在高危乳腺癌组织中可见TAMs,故将其作为重要的治疗靶点.随着对TAMs的深入研究,会进一步改善乳腺癌疗效及预后.

Tumor-associated macrophages （TAMs） produce factors that promote angiogenesis,tissue remodel and decrease the immune response to tumors.Specific macrophage types contribute to increased metastases in animal models,while human studies have shown an association between TAMs and tumors with poor prognostic features.Macrophages display a spectrum of phenotypic states.Tumor microenvironment could turn TAMs into a ‘ nonclassical’ activation state,known as the M2,or wound healing/regulatory state.These TAMs are found in high-risk breast cancer tissues indicating that they might be an important therapeutic target.Further understanding of TAMs should benefit the clinical treatment of breast cancer.