外科植入硅橡胶材料钙化及抗钙化研究进展

Research progress of calcification and anti-calcification of implanted silicone rubber

硅橡胶钙化是材料植入体内后其表面或基质内出现病理性矿化的现象,尚无有效防治方法.钙化的重要过程是材料表面的磷酸根离子与钙离子结合启动成核聚集,缓慢增大、融合,逐渐形成较大的羟基磷灰石钙盐堆积.其研究已发展到细胞和基因水平,如基质Gla蛋白质簇是一种硅橡胶假体周围组织钙化的抑制因子.钙化过程中有机模板对无机晶体的调制作用需理论上的突破.硅橡胶自身局部抗钙化性能受到重视.揭示硅橡胶钙化和钙化抑制的机理,可为构建新型抗钙化功能材料提供依据.

Calcification of silicone rubber is a pathologic mineralization phenomenon which occurs on the surface after it is implanted in vivo,and there is no effective prevention method.The important process of calcification including these steps：phosphate ions combined with calcium ions to promote nucleating aggregation,slow increasing,fusion,and gradually form a larger accumulation of hydroxyapatite calcium.The research had been developed to the level of cells and genes,such as matrix Gla protein clusters is a calcification inhibitor of the tissues around silastic prosthesis.It is necessary to obtain a theoretical breakthrough in the aspect of organic template modulation of inorganic crystals.Silicone elastomer having its own local anti-calcification property had been paid more attention.Fully revealing the mechanism of calcification and calcification-resistant of silicone rubber will probably provide the basis for building a new anti-calcification material.