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雄激素受体基因CAG多态性与前列腺癌的关系 被引量：3

The role of androgen receptor gene CAG polymorphism in prostate cancer
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摘要 目的 :进一步探讨雄激素受体 (AR)基因 CAG多态性与前列腺癌的关系。方法 :采用分子生物学方法对 35 8例前列腺癌患者 AR基因 CAG进行测试 ,分析 CAG长度与临床各种指标的关系。结果 :经统计学分析 ,显示 AR基因 CAG与年龄之间呈高相关性 (P =0 .0 0 7,γ=0 .114) ,但与 PSA、肿瘤分级及分期无显著相关性。结论 :AR基因 CAG的长度与患者年龄成正比 ,即前列腺癌患者年龄越轻 ,其 CAG长度越短。 Purpose:To further assess the role of androgen receptor gene CAG polymorphism in prostate cancer. Methods:DNA from 358 patients with prostate cancer were assayed for the number of CAG repeats. The length of CAG triplets and different clinical parameters were evaluated including age, PSA, stage, grade. Results:Only significant association between age at diagnosis and the length of CAG repeats was observed(P= 0.007 ,γ= 0.114 ).Conclusions:It was revealed from this study that the decreased number of AR gene CAG triplets was associated with the younger patient with prostate cancer at diagnosis.
作者 陈越 Beilin J Zajac J D Favaloro J N Davey R Byron K Harewood H 唐涌志 孟荟
机构地区 上海市静安区中心医院泌尿外科 澳大利亚皇家墨尔本医院内科 澳大利亚皇家墨尔本医院分子生物实验室 澳大利亚皇家墨尔本医院泌尿外科
出处 《临床泌尿外科杂志》 2001年第2期51-53,共3页 Journal of Clinical Urology
关键词 雄激素受体 CAG片断 前列腺癌 基因多态性 Androgen receptor CAG triplet Prostate cancer
分类号 R737.25 [医药卫生—肿瘤] R730.23 [医药卫生—肿瘤]
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参考文献10

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同被引文献18

  • 1陈昭,王建美,高顺强.痤疮病因研究进展[J].中国煤炭工业医学杂志,2005,8(2):107-108. 被引量：22
  • 2于中蛟,陆洁,段昕所.痤疮与雄激素关系的研究进展[J].承德医学院学报,2005,22(4):348-350. 被引量：14
  • 3Kawakami T, Watabe H, Mizoguchi M, et al. Elevated serum IgA anticardiolipin antibody levels in adult Henoch - Schonlein purpura. Br J Dermatol,2006,155 : 983 - 987.
  • 4Multhoff G. Heat shock proteins in immunity. Handbook of Experimental Pharmacology. Germany : Springer - Verlag, 2006 : 279 - 304.
  • 5Ruchhaus M,Gross M,Schulz S,et al. The E - selectin SER128ARG gene polymorphism and restenosis after successful coronary angioplasty. Int J Cardiol,2002,83:249 -257.
  • 6Irvine RA,Yu MC,Ross RK,et al. The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer. Cancer Res, 1995,55:1937 -1940.
  • 7Hickey T, Chandy A, Norman RJ. The androgen receptorCAG repeat polymorphism and Ⅹ - chromosome inactivation in Australian Caucarsian women with infertility related to polycysti covary syndrome. J Clin Endocrinol Metab,2002,87:161 -165.
  • 8Andrew SE, Goldberg YP, Hayden MR, et al. Rethinking genotype and phenotype correlations in polyglutamine expansion disorders. Hum Mol Genet, 1997,6:2005 - 2010.
  • 9Ferro P, Catalano MG, Dell' Eva R, et al. The androgen receptor CAG repeat:a modifier of carcinogenesis? Mol Cell Endocrinol, 2002,193 : 109 - 120.
  • 10Yong EL, Lira J, Qi W, et al. Molecular basis of androgen receptor diseases. Ann Med ,2000,32 : 15 - 22.

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临床泌尿外科杂志
2001年 第2期

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