膀胱移行细胞癌微血管密度与肿瘤复发的关系

Intratumor mirovessel density and recurrence of transitional cell carcinoma of the bladder

目的 :探讨肿瘤微血管形成能力与膀胱移行细胞癌复发的关系及其机制。方法 :采用免疫组织化学方法对 2 5例膀胱移行细胞癌组织中的第 因子相关抗原、碱性成纤维细胞生长因子 (b FGF)及血管内皮细胞生长因子 (VEGF)分别进行特异性染色 ,计数肿瘤内微血管密度 (i MV) ,并观察 b FGF、VEGF的表达。结果 :VEGF和 b FGF的阳性表达率分别为 48%和 2 8% ,阳性表达组 i MV显著高于阴性表达组 (P <0 .0 5 ) ,术后复发组 i MV显著高于未复发组 (P <0 .0 5 ) ,且高 i MV组复发率高于低 i MV组 (P <0 .0 5 )。结论 :i MV与膀胱移行细胞癌复发有关 。

Purpose:To evaluate angiogenesis and its correlation to recurrence of transitional cell carcinoma of the bladder.Methods:Specimens from 25 patients with transitional cell carcinoma of the bladder were assayed using immunohistochemical technique to examine the expression of factor Ⅷ related antigen, basic fibroblast growth factor(bFGF) and vessel endothelial growth factor(VEGF), as well as the microvessel density.Results:The positive rate of VEGF and bFGF was 48% and 28%. The intratumor microvessel density(iMV) of tissues with positive staining was significantly higher than thos with negative staining(P< 0.05 ),and the iMV of patients with recurrence was significantly higher than those without recurrence(P< 0.05 ).Conclusions:iMV correlated positively with recurrence and the expression of VEGF and bFGF was related to the function of angiogenesis in transitional cell carcinoma of the bladder.