Pgp、mP53和EGFR表达预测表浅性膀胱癌复发的价值

Significance of overexpression of P-glycoprotein, mutant P53 protein and epidermal growth factor receptor in primary superficial transitional cell carcinoma of bladder

目的 :探讨 P糖蛋白 (Pgp)、突变 P5 3蛋白 (m P5 3)和表皮生长因子受体 (EGFR)表达在预测表浅性膀胱癌复发方面的价值。方法 :应用免疫组织化学 SP法检测 46例随访 3年以上、术前未经化疗的原发性表浅膀胱移行细胞癌标本中 Pgp、m P5 3和 EGFR的表达情况。结果 :Pgp、m P5 3和 EGFR的阳性表达率分别为 45 .7%、5 8.7%和 5 2 .2 % ,单因素 Kaplan- Meier生存分析显示 Pgp、m P5 3和 EGFR表达与术后复发相关 ;多因素 Cox回归分析显示术后复发与 Pgp、m P5 3表达有关 ,而与 EGFR表达无关。结论 :Pgp、m P5 3过度表达是判定原发性表浅膀胱移行细胞癌复发的重要指标。

Purpose:To investigate the prognostic value of P glycoprotein(Pgp), mutant P53 protein and epidermal growth factor receptor (EGFR) expression in primary superficial transitional cell carcinomas(TCCs) of bladder.Methods:Specimens from 46 patients with untreated superficial bladder TCCs were analyzed for the expression of Pgp,mutant P53 and EGFR respectively and their clinical data were obtained by follow up for over 3 years.Results:Pgp, mutant P53 protein and EGFR were positive in 45.7 %, 58.7 % and 52.2 % respectively. A strongly inverse relationship between the expression of Pgp, mutant P53 and EGFR and disease free survival (DFS)could be demonstrated by Kaplan Meier survival analysis. Multivariate analysis(Cox regression)indicated that DFS or recurrence was associated with overexpression of Pgp and mutant P53 protein, no significant correlation between EGFR overexpression and recurrence was found.Conclusions:Overexpression of Pgp, mutant P53 can be used as the important prognostic factor of recurrence of superficial TCCs.