MMC和BCG交替灌注防治膀胱癌术后复发

Clinical results of intravesical instillation with MMC and BCG for the prevention of postoperative recurrence of bladder tumor

目的 :观察丝裂霉素 C(MMC)和卡介苗 (BCG)化学免疫预防膀胱癌术后复发的疗效。方法 :对 86例浅表性膀胱癌患者术后应用 MMC 2 0 mg和 BCG 6 0 m g,每周 1次进行交替膀胱灌注 ,共灌注 12次 ,以后每间隔 3个月灌注 1次 ,持续 2年。结果 :随访 2 .4～ 8年 ,平均 4.8年 ,肿瘤复发率为 8.1%。结论 :MMC和 BCG交替膀胱灌注可减少膀胱癌术后复发率。

Purpose:To investigate the clinical results of intravesical instillation with MMC and BCG for the prevention of postoperative recurrence of bladder tumor.Methods:86 cases of patients with superficial bladder cancer were included in this study. All patients received intravesical instillation of 20 mg MMC or 60mg BCG in turn once a week postoperatively, and persisted for 12 weeks. Then intravesical instillation was performed every 3 months, persisted for 2 years.Results: All patients have been followed up for 2.4 to 8 years, with a average of 4.8 years. The recurrent rate was 8.1 %.Conclusions:Intravesical instillation of MMC and BCG in turn are effective for reducing the postoperative recurrence rate of bladder tumor.