2型糖尿病患者视网膜病变与骨密度的研究

Study of diabetic retinopathy and Bone Mineral Density in type 2 Diabetes patient

目的:探讨2型糖尿病患者视网膜病变(DR)与骨密度(BMD)的关系。方法:检查了63例2型糖尿病患者视网膜,分为A组即正常组、B组单纯性视网膜病变组、C组增殖性视网膜病变组,并分别测定其L2～4椎体、双侧股骨Ward区BMD。结果:除A组患者BMD与对照组无明显差异(p>0.05);B、C组患BMD与对照组差异明显(p<0.01);糖尿病患者中,C组BMD明显低于A组(p<0.01)。结论:糖尿病视网膜病变患者BMD比正常人低,增殖性视网膜病变组BMD较其它组显著下降。

Objective：To study the relationship between diabetic retinopathy and bone mineral density with type 2 diabetic patients （T2DM） .Methods：Dual energy X -ray absorptiometry was used to measure the bone mineral density （BMD） of lumbar spines（L2 -4） , Ward＆#39;s triangle in 63 patients with type 2 diabetes mellitus and 55 cases of normal control group .According to diabetic retinopathy were divided into groups with normal retina （group A）, nonproliferative diabetic retinopathy （group B） and proliferative diabetic retinopa-thy （ group C） .Results：No significant differences were found in BMD between normal retina l diabetic patients and normal control group （ p ＆gt;0.05） .BMD was significantly lower in diabetes patient with nonproliferative diabetic retinopathy group and proliferative diabetic retinopathy than the normal control group .In diabetes patient BMD was significantly lower in proliferative diabetic retinopathy group than in normal control groups （ p ＆lt;0.01） .Conclusion：BMD in diabetes patient with nephropathy should be lower than normal control group.BMD in diabetes patient might be more remarkable in the group with proliferative diabetic retinopathy than in the groups with nor -mal retina and nonproliferative diabetic retinopathy .