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参麦注射液对STEMI患者直接PCI术后冠脉微循环的影响 被引量:2

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摘要 目的:观察参麦注射液对ST段抬高型心肌梗死(STEMI)患者直接经皮冠状动脉支架植入术(PCI)后冠脉微循环的影响。方法:60例接受直接PCI治疗的急性STEMI患者,随机分为对照组和治疗组(参麦注射液组)各30例。观察PCI术前及术后1天、7天一氧化氮(NO)含量、丙二醛(MDA)含量、内皮型一氧化氮合酶(eNOS)、诱导型一氧化氮合酶(iNOS)及超氧化物歧化酶(SOD)活性变化情况;术后冠脉血流及90分钟心电图ST段回落率变化。结果:(1)术后NO含量、eNOS活性均下降,iNOS活性增高,但治疗组术后1天、7天NO含量、eNOS活性均高于对照组,iNOS活性低于对照组,差异具有统计学意义(P<0.01);(2)术后SOD活性下降,MDA含量明显增高。但治疗组术后1天、7天SOD活性高于对照组,MDA含量低于对照组,差异具有统计学意义(P<0.01);(3)2组患者术后梗死相关动脉(IRA)的TIMI3级血流获得率无统计学意义差异(P﹥0.05),但参麦注射液组90分钟心电图ST段回落率快于对照组(P﹤0.05)。结论:参麦注射液可加快急性心梗直接PCI术后心电图ST段回落率,改善微循环,且可能通过改善血管内皮功能,减轻氧化损伤机制而发挥作用。
作者 连瑞珍
机构地区 包钢医院心内科
出处 《中国伤残医学》 2014年第6期134-136,共3页 Chinese Journal of Trauma and Disability Medicine
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