临床孤立综合征相关生物标记物的研究进展

Advances of biomarkers related to clinically isolated syndrome

临床孤立综合征(CIS)是一种中枢神经系统(CNS)脱髓鞘事件单次发作的综合征,常为多发性硬化(MS)的首发表现,给家庭以及社会造成沉重的经济和精神负担,目前需要将能够简化CIS诊断、判断疾病进程、反映药物疗效和安全性的行之有效的生物标记物尽快应用于临床。本文就一些新的CIS诊断、预后和治疗反应相关生物标记物进行综述。

Clinically isolated syndrome（CIS） is a syndrome of single episode of demyelinating affair which maybe the onset of multiple sclerosis. It will cause severe economic and psychological burdens to both family and society. New biomarkers are in urgent need to simplify the diagnosis of CIS, to judge the progress of disease,and to reflect the efficacy and safety of treatment. Here, we give a simple review of some new biomarkers about diagnosis, prognosis prediction and therapy responses of CIS.