化痰活血退黄汤联合西药治疗难治性高黄疸11例临床观察

Combine Traditional Chinese and Western Medicine Treatment of Refractory High Jaundice Huatan Huoxue Tuihuang Decoction 11 Cases Clinical Observation

[目的]观察化痰活血退黄汤联合西药治疗难治性高黄疸疗效。[方法]使用前瞻性设计方法,对11例住院患者使用化痰活血退黄汤(赤芍20g,制半夏、陈皮、生大黄10g,泽泻20g,茵陈30g),1剂/d,水煎250mL,早晚温服。明确原发病的基础上针对病因治疗、对症西医治疗。连续治疗14d为1疗程。观测临床症状、胆红素、血脂及载脂蛋白、不良反应。连续治疗4疗程,判定疗效。[结果]治疗组显效4例,有效4例,无效3例,总有效率72.73%。血清总胆红素(TBIL)、直接胆红素浓度(DBIL)、直接胆红素占总胆红素比例(DB/TB)均有改善(P<0.01,P<0.05)。胆固醇(CHOL)、甘油三脂(TG)、低密度脂蛋白(HDL)和高密度脂蛋白(LDL)均有改善(P<0.05)。[结论]化痰活血退黄汤联合西药治疗难治性高黄疸效果显著,值得推广。

[ Objective ] Huatan Huoxue Tuihuang decoction combined with western medicine high efficacy in refractory jaundice. [ Method ] Method using a prospective design, in 11 cases of hospitalized patients with Huatan Huoxue Tuihuang decoction （ Chishao 20g, Zhibanxia, Chenpi, Dahuang 10g, Zexie 20g, Yinchen 30g ）, 1 dose/d, decoction 250mL, morning and evening, warm clothes. On the basis of a clear primary disease treatment for the cause, symptomatic treatment of Western medicine. 14d is a continuous course of treatment. Observation of clinical symptoms, bilirnbin, blood lipids and apolipoproteins, adverse reactions. 4 continuous treatment regimen to determine efficacy. [ Results ] Treatment group 4 cases had marked effect, 4 cases were effective, ineffective in 3 patients, the total efficiency of 72.73%, the clinical efficacy of the treatment group than the control group. Serum total bilirubin （ TBIL ）, direct bilirubin concentration （ DBIL ） and direct bilirubin proportion of total bilirubin （ DB / TB ） were improved （ P〈0.01, P〈0.05 ） . Cholesterol （ CHOL ）, triglyceride （ TG ）, low-density lipoprotein （ HDL ） and high-density lipoprotein （ LDL ） were improved （ P〈0.05 ） . [ Conclusion ] Huatan Huoxue Tuihuang decoction combined with western treatment of refractory high jaundice effect is significant, it is widely in clinical practice.