痰瘀互结型不稳定型心绞痛与低密度脂蛋白胆固醇、甘油三酯相关性系统综述

Systematic Review of A Correlation Between Blood-Lipoid and Phlegm Accumulate with Stagnant Blood Syndrome Type of Unstable Angina and Low-Density Lipoprotein Cholesterol Triglycerides

[主要目的]分析痰瘀互结型不稳定性心绞痛与低密度脂蛋白胆固醇、甘油三酯相关性。[资料来源]在辽宁中医药大学附属医院病案室,选取2012年1月至2012年8月辽宁中医药大学附属医院心内科不稳定型心绞痛住院患者病历。[选择文献量及依据]①研究类型:临床观察。②研究对象:入院后确诊为不稳定性心绞痛。中医四诊资料齐全;同一患者反复入院症状发生变化时重复纳入,无明显变化时仅纳入第一次入院情况。③诊断分型:气阴两虚兼血瘀、痰瘀互结、气滞血瘀、阳虚水泛、气虚血瘀;血脂异常诊断标准参照《中国成人血脂异常防治指南》。④评价指标:LDL-C、TG化验指标。[数据提炼规则及应用方法]在系统研究UA文献基础上,筛选与UA相关危险因素,制定"影响不稳定型心绞痛多因素调查表"。查阅UA住院患者病历及其化验单,填写"影响不稳定型心绞痛多因素调查表",选取LDL-C与TG结合中医证型进行分析。[数据综合得出结果与结论]痰瘀互结异常低密度脂蛋白与甘油三酯所占构成比及低密度脂蛋白与甘油三酯测量值较其他四组显著升高(P<0.01)。胸痹痰瘀互结型临床主要有胸闷如滞、气短痰多、舌苔浊腻、脉滑等,与不稳定性心绞痛患者血脂、生化、凝血检查的浓、黏、凝、聚的特点尤为相似。[未来展望]今后能加强相关研究,为不稳定型心绞痛中医辨证分型提供客观化指标,为中医证候学研究提供理论依据。

[ Objective ] To investigate a correlation between the unstable angina （ UA ） in Phlegm accumulate with stagnant blood syndrome type and blood-lipid. [ Materials source ] To select the records of the patients of unstable angina between Jan, 2012 and Ags.2012 in the medical records room, department of cardiology in Affiliated Hospital of Liaoning University of Tranditional Chinese medicine. [ Quantities and criteria ] 1.Research type： clinical observation. 2. Research objects： After admission diagnosis of unstable angina. TCM four diagnostic data is complete; Repeated the same patients admitted to hospital symptoms change repeat into, no obvious changes include only admitted for the first time.3.Diagnostic classification：Qi and Yin deficiency and blood stasis, phlegm and blood stasis, and qi stagnation and blood stasis, Yang deficiency water pan qi deficiency and blood stasis; Dyslipidemia diagnosis standard referenceChina＇s adult dyslipidemia prevention guide.4.Evaluation indicator：Assay index of LDL-C, TG. [ Data extraction rules and methods of application ] On the basis of systematic research UA literature, screening of risk factors associated with UA, formulated ＂factors affecting more unstable angina questionnaire＂.Access to medical records and hospitalized patients with UA paper, fill in ＂factors affecting more unstable angina questionnaire＂, selection of LDL - C and TG analysis combined with TCM syndrome type. [ Data synthesis results and conclusions ] Phlegm and blood stasis mutual junction abnormal low density lipoprotein and triglyceride composition ratio and low density lipoprotein and triglyceride of measured values than other four groups increased significantly （ P〈 0.01 ） . Clinical main obstruction of phlegm and blood stasis mutual junction with chest distress such as hysteresis, shortness of breath much sputum and turbidity greasy tongue coating, pulse, etc., and unstable angina patients blood lipids, biochemical, blood coagulation inspection of thick, sticky, coagulation, particularly similar characteristics.. [ Future prospect ] Enlarge the sample size, the thorough research, for mutual junction phlegm and blood stasis unstable angina treatment provided the scientific basis.