中药干预阿司匹林抵抗研究简况

Research Overview of Chinese Medicine Intervention on Aspirin Resistance

阿司匹林抵抗可能与血小板激活替代途径、阿司匹林对血栓素生物合成不敏感、药物间相互作用及剂量过低等因素有关。许多中药具有很好的抗血小板聚集作用,可改善阿司匹林抵抗。单味中药(补益、活血化瘀、理气)、复方(益气活血、温阳活血、滋阴活血,包括自拟方、成方、经方等);中药提取成分(丹参、汉防己、丁香油、芹菜素、毛地黄、穿心莲、虎杖根茎、灯盏花、绞股蓝、大蒜素、三七、槲皮素、葛根素等)均能有效抑制血小板聚集,得到广泛研究,临床效果好,价格低廉,依从性好。

Aspirin resistance may be associated with activation of the alternative pathway of platelet, aspirin on thromboxane biosynthesis is not sensitive to factors between drug interactions and dosage is too low and so on. Many traditional Chinese medicine has a good anti-platelet aggregation effect of aspirin resistance can be improved. Single herb （ invigoration, blood circulation, regulating qi ）, the compound （ supplementing Qi and activating blood circulation method , warming yang and promoting blood circulation, Nourishing Yin and Promoting Blood Circulation, including self-prescription, set- prescription, classical prescription, etc.） ; extracted components from chinese medicinal herbs （Salvia, tetrandrine, cloves oil, apigenin, luteolin, Andrographis, knotweed rhizome, erigeron, Gynostemma, allicin, Panax, quercetin, puerarin, etc. ） can effectively inhibit platelet aggregation, has been widely studied, and achieved better clinical results, while inexpensive, and good compliance.