龈沟液中天冬氨酸转氨酶和碱性磷酸酶水平相关性的研究

The study of the correlation between the activities aspartate aminotransferase(AST) and alkaline phosphatase(ALP) in gingival crevicular fluid

目的 观察成人牙周炎龈沟液中天冬氨酸转氨酶 (AST)和碱性磷酸酶 (ALP)水平的相关性 ,并探讨两种酶在牙周炎活动性诊断中的意义。方法 利用全自动生化分析仪检测 6 0例成人牙周炎患者共 72个位点、15例健康对照 15个位点龈沟液中AST、ALP水平 ,并进行分析。结果 成人牙周炎患者龈沟液中AST、ALP两种酶之间具有一定的相关性 ,二者均与探诊深度、附着丧失、牙龈指数呈正相关关系 ,其中总量与临床指标相关性更高。结论 龈沟液中AST、ALP浓度和总量 (特别是总量 )均反映牙周炎的严重程度 ,可用于牙周炎活动性的监测。

Objective To observe the possible correlation between the aspartate aminotransferase(AST) and alkaline phosphatase(ALP) in gingival crevicular fluid(GCF) in adult peridontitis patients and to evaluate the diagnostic value of two indicators for the activity of periodontitis. Methods To measure seventy two sites in 60 adult periodontitis patients GCF AST and GCF ALP levels in GCF by automatic analysis. Results GCF AST and GCF ALP levels were much higher in adult periodontitis patients than in healthy controls.AST and ALP were found to have positive correlation with clinical parameters such as PD、CAL、GI and with each other,both when expressed as total amounts and concentrations.We also found total amounts showed consistently higher correlation conefficients as compared to concentrations. Conclusion These results indicate that both AST and ALP levels in GCF may be considered as potential markers for the activity of periodontitis.