50例腋淋巴结转移瘤活检的病理学分析

Pathological Analysis of Metastasis of Axillary Lymph Node by Biopsy in 50 Cases

目的探究腋淋巴结转移瘤的病理学特征,为诊断和治疗提供有力的证据。方法回顾性分析2008年至2013年我科诊断的50例腋淋巴结转移瘤患者,对患者年龄、性别、转移瘤原发部位进行统计,并对其中已知原发瘤部位(MKO)的35例(男10例、女25例)年龄、受累及淋巴结侧位、转移瘤基本组织学类型等与原发瘤部位分析。应用免疫组织化学标记,研究腋淋巴结转移瘤组织雌激素受体(ER)、Her-2和Ki-67的表达。结果女性患者的年龄总体上显著低于男性,并且女性年龄分布范围较广泛。腋淋巴结转移主要为腺癌,原发部位主要为乳腺、肺、食管、子宫颈等。结论腋淋巴结转移瘤在女性主要考虑来自局部引流区域,在男性则主要考虑来自胸腔和腹腔器官。

Objective Explore the pathological features of metastases of axillary lymph node to provide strong evidence for diagnosis and treatment. Methods A retrospective analysis was taken in 50 cases of axillary lymph node metastases from 2008 to 2013 in our department. Age,gender, primary site of metastases of the patients were analyzed,and the relationship between some pathologic parameter and the primary sites of 35 patients（ male 10,female 25） in metastasis of known origin（ MKO） were especially analyzed,the ER,Her-2 and Ki-67 were detected by immunohisto- chemical. Results The age of female patients was significantly lower than men,and the females＇ distribution of age broader than males＇. Axillary lymph node metastases was mainly adenocarcinoma,and the number of the primary tumor site in female was more than male. Metastatic tumors were mainly from the breast,lung,esophagus,endometrium,cervix,skin,parts of the wrist,et al. Conclusion Axillary lymph node metastases in women were from the local drainage system,however in men were mostly from chest and abdominal organs.