神经衰弱及抑郁症患者事件相关电位P300对照研究

Control study on event related potentials P300 in patients with neurasthenia and depression

目的探讨神经衰弱和抑郁症患者在事件相关电位(ERP)P300的不同表现。方法收集2012年3月至2013年3月湛江中心人民医院35例神经衰弱患者和32例抑郁症患者以及35例健康成人进行ERP测定,采用日本光电诱发电位仪以听觉Oddball刺激序列刺激,完成P300测量。结果与健康对照组比较,神经衰弱组P300潜伏期延长;抑郁症组P300潜伏期延长,波幅降低,差异均具有统计学意义(P<0.05)。神经衰弱组与抑郁症组比较,抑郁组P300潜伏期延长及波幅降低明显,差异具有统计学意义(P<0.05)。结论抑郁症患者认知功能受损较神经衰弱患者更为显著,P300作为与认知相关的诱发电位,可为神经衰弱及抑郁症患者的诊断及鉴别诊断提供脑电生理方面的依据。

Objective To investigate the changes of event-related potentials P300 in patients with neurasthenia and depression .Methods Event-related potentials P300 were recorded form 35 neurasthenia patients and 32 depres-sion patients ,compared with 35 healthy adults in control group by using Nihon Kohden instruments .Results Com-pared with the healthy adult in control group ,the latency of P300 was longer（P＆lt;0 .05）in the patients with neuras-thenia;the latency of P300 was longer and the amplitude of P300 was lower in the patients with depression （P＆lt;0 .05） .The latency of P300 in the patients with depression was longer than in the patients with neurasthenia ,the am-plitude of P300 in the patients with depression was lower than in the patients with neurasthenia （P＆lt;0 .05） .Conclu-sion Neurasthenia and depression are different in the features of P300 ,impaired cognitive function was even more serious in the patients with depression .P300 could provide an electrophysiology basis for the diagnosis and differenti-al diagnosis for neurasthenia and depression .