摘要
目的:评估胃食管反流病(GERD)维持治疗的疗效及影响因素。方法:通过症状评分、内镜检查、食管压力测定和24h食管pH监测等方法,调查73例GERD患者对维持治疗的反应并分析其有关影响因素。结果:间断治疗有效组(间断组)患者40例,维持治疗有效组(维持组)30例,治疗无效组(无效组)3例。间断组患者病程较维持组短(P<0.001),下食管括约肌压力(LESP)和上食管括约肌压力(UESP)均比维持组高(P<0.05),食管体部蠕动收缩波幅高于维持组,但无显著差异;间断组患者内镜下反流性食管炎(RE)以0级和Ⅰ级为主,而维持组以Ⅲ级为主(P<0.01);症状评分和24 h食管pH监测结果在间断组和维持组患者间无显著差异。结论:有些GERD患者的远期治疗可采取间断维持的方式,RE的严重程度和LESP减低是决定是否需长期维持治疗的重要预测因素。
Background/Aims: To evaluate the effectiveness of maintenance therapy and its influencing fac- tors in patients with gastroesophageal reflux disease (GERD). Methods: 73 patients with confirmed GERD were investigated in the response to maintenance therapy and its influencing factors using symp- toms scoring, endoscopy, esophageal manometry and 24-hour pH monitoring. Results: There were 40 patients in the intermittent maintenance therapy (IMT) group, 30 in continuous maintenance therapy (CMT) group and 3 in ineffective therapy (IT) group. The course of GERD in IMT group was signifi- cantly shorter than that in CMT group (P<0.001). Lower esophageal sphincter pressure (LESP) and upper esophageal sphincter pressure (UESP) in IMT group were higher than those in CMT group (P< 0.05). Endoscopy in IMT group displayed less severe renux esophagitis (RE) than that in CMT group (P<0.01). There was no significant difference in reflux symptoms and 24-hour pH esophageal moni- toring between IMT and CMT groups (P>0.05). Conclusions: Intermittent form may be used in pa- tients with long-term maintenance therapy. Seventy of RE and decreased LESP are important predic- tive factors of long-term maintenance therapy.
出处
《胃肠病学》
2000年第4期211-213,共3页
Chinese Journal of Gastroenterology
关键词
胃食管反流
食管胃接合处
GERD
影响因素
维持治疗
Gastroesophageal Reflux
Esophagitis, Peptic
Esophagogastric Junction
Clinical Protocols