腮腺腺样囊性癌中PTEN、MDM2表达

Adenoid Cystic Carcinoma of Parotid Gland Expression of PTEN and MDM2

目的:研究腮腺腺样囊性癌组织中抑癌基因PTEN、癌基因MDM2蛋白表达,探讨PTEN、MDM2在腮腺腺样囊性癌中两者之间的相关性,为将来临床应用提供参考。方法:选取腮腺腺样囊性癌手术存档石蜡标本30例,另取10例腮腺腺样囊性癌癌旁正常组织石蜡标本作为对照组,采用免疫组化SP法检验PTEN、MDM2表达情况。结果:腮腺腺样囊性癌和癌旁正常组织中PTEN蛋白的阳性率分别为20%(6/30)和70%(7/10),二者存在显著性差异(P<0.05)。MDM2蛋白在两种组织中阳性率分别为66%(20/30)和20%(2/10)(P<0.05),二者存在显著性差异(P<0.05)(r=-0.657),在腮腺腺样囊性癌中PTEN、MDM2的表达负相关。结论:PTEN、MDM2蛋白异常表达在腮腺腺样囊性癌的发生发展中起重要作用。

Objective： To study the expression of PTEN and MDM2 in the tissue of adenoid cystic carcinoma of parotid gland, investigate the correlation between PTEN and MDM2 to provide the reference for future clinical applications. Method： 30 cases of cancer tissues and 10 cases of noncancerous tissues were stained with PTEN and MDM2 by immunohistochemical method. Result： The positive rate of PTEN protein in cancerous tissue and normal tissue was 20% （6/30） and 70% （7/10）, they exist significant difference （P〈 0.05）. The positive rate of MDM2 protein in the two kinds of organizations was 66% （20/30） and 20% （2/10） （P〈0.05）, they exist significant difference （P 〈0.05） （r = -0.657）. The expression of PTEN and MDM2 in cancer tissues was negatively correlated. Conclusion： The expression of PTEN and MDM2 protein plays an important role in the occurrence and development with adenoid cystic carcinoma of parotid gland.