血栓通对急性脑梗塞患者血清D-二聚体和超敏C反应蛋白的作用

Effect of Xueshuantong on Serum D-dimer and High Sensitivity C-reactive Protein in Patients with Actue Cerebral Infarction

目的:观察血栓通对急性脑梗死(actue cerebral infarction,ACI)患者血清D-二聚体和超敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)水平的影响。方法:将68例ACI患者随机分为观察组和对照组。两组进行常规治疗,观察组加用血栓通0.5 g/d,静滴。于治疗前、治疗后3 d、7 d和14 d检测患者血清D-二聚体和hs-CRP浓度变化,比较两组治疗前后改良爱丁堡-斯堪的纳维亚神经功能评分(MESSS)及日常生活能力Barthel指数(BI)的变化。结果:观察组在治疗后3 d、7 d和14 d,血清D-二聚体和hs-CRP浓度较对照组明显降低(P<0.05),MESSS和BI评分在治疗后7 d和14 d较对照组明显改善(P<0.05)。观察组的显效率和总有效率高于对照组(P<0.05)。结论:血栓通可降低ACI患者血清D-二聚体和hs-CRP水平,改善神经功能,是一种有效治疗急性脑梗塞的方法。

Objective： To observe the effect ofxueshuangtong on serum D-dimer and high sensitivity C-reactive protein in patients with ACI. Methods： Sixty-eight patients with ACI were randomly divided into two groups. One group received conventional treatment （control group） and the other received additional intravenous drip 0.5 g of xueshuantong per day besides conventional medications （treatment group）. Serum concentrations of D-dimer and hs-CRP in the two groups were measured before the treatment and on 3 rd, 7 th and 14 th day respectively after treatment. Results： Compared with control group, the serum levels of D-dimer and hs-CRP in treatment group decreased significantly on the 3rd, 7th and 14th day after treatment （P 〈 0.05）, while scores of MESSS and BI in treatment group improved obviously on 7 th and 14 th day after treatment （P 〈 0.05）. The markedly effective rate and the total effective rate of treatment group were significantly than those of control group （P 〈 0.05）. Conclusion： Xueshuangtong may reduce serum levels of D-dimer and hs-CRP and have neurprotection role. The results showed that Xueshuangtong may represent an effective treatment of ACI.