脐带间充质干细胞治疗粉碎性骨折1例并文献复习

The Treatment of One Case Comminuted Fractures with Umbilical Cord Mesenchymal Stem Cell Transplantation and Literature Review

目的：观察脐带间充质干细胞治疗粉碎性骨折的疗效和安全性。方法：将脐带间充质干细胞通静脉输注和局部多点注射到常规治疗效果欠佳自愿接受干细胞移植的1例粉碎性骨折患者，4次为一个疗程，每周间隔1次，每次治疗细胞总数（3～7）×10^7。术后1、3、6月定期观察患者临床症状及影像学的变化并进行动态观察。结果：脐带间充质干细胞治疗后一月，患者在不帮助的情况下可独立缓慢行走，复查X线提示骨折部位有新生骨形成；干细胞治疗后三月，复查X线提示骨折愈合较前好转；半年后，患者右下肢受力明显好转，可以独立自由行走，复查X线提示右下肢骨折部位有连续性骨痂形成，骨折部位愈合良好。结论：脐带间充质干细胞移植治疗粉碎性骨折是一种安全、有效的手段，可促进粉碎性骨折的愈合，改善其生活质量。

Objective： To observe ＇the clinical effect and safety of umbilical cord mesenchymal stem cell（UC-MSC） transplantation in the treatment of comminuted fractures. Methods： One patient with comminuted fractures were received UC-MSC transplantation [4 times as a course of treatment which every time interval one week, cell numbers（3-7）× 10^7/time]by intravenous infusion and local lesion multipoint injections. Clinical symptoms and change of iconography were observed from 1, 3 and 6 month after stem cell treatment. Results： After one month of UCB-MSC transplantation, the patient can walk slowly without help, and X-ray rechecked show new bone formation of fracture site. X-ray rechecked show fracture healing improved after three month of UCB-MSC transplantation. The strength of right lower extremity of the patient strengthen, walk freely without help, continous callus formation of fracture site which hinted fract- ure site healing was better. The patient had no severe complications and clear side effects after transplantation. Conclusions： UCB-MSC transplantation is effective and safe method in the treatment of comminuted fracture. It can promote the healing of comminuted fracture and improve the quality of life.