产后与非产后抑郁症患者记忆功能的对比研究

Comparative Study on the Memory Function between Postpartum and Non Postpartum Depression

目的:探讨产后与非产后抑郁症患者记忆功能的差异,为产后抑郁症患者的早期预防提供参考依据。方法:通过17项汉密尔顿抑郁量表和韦氏记忆评定解放军第三医院2011年1月至2012年11月收治的40例产后抑郁症患者(产后组)、42例非产后抑郁症患者(非产后组)的记忆功能,并与42名健康志愿者(对照组)的结果进行比较。结果:(1)与对照组比较,产后组长时记忆评分与其比较差异不显著(P>0.05),除触摸因子外,短时记忆各因子评分均显著降低(P<0.05),瞬时记忆评分、记忆商均明显降低(P<0.05);非产后组长时记忆评分显著降低(P<0.05),除联想、理解因子外,短时记忆评分差异均不显著(P>0.05),瞬时记忆、记忆商评分均显著降低(P<0.05)。(2)与产后组相比,非产后组长时记忆评分显著降低(P<0.05),短时记忆图片、再认因子评分显著升高(P<0.05),联想、触摸、理解因子差异不显著(P>0.05),瞬时记忆、记忆商评分差异不明显(P>0.05)。结论:产后与非产后抑郁症患者的记忆功能均下降,但受损成分不同,产后抑郁患者的记忆功能受损只是一种功能性受损。

Objective： To explore the difference of memory function between postpartum and non postpartum depression, and provide references for the early prevention of the postpartum depression. Methods： 40 cases of postpartum depression （postpartum depression group） and 42 cases of non postpartum depressions （non postpartum depression group） hospitalized in Third Hospital of PLA from January 2011 to November 2012 were assessed by 17-item Hamilton Depression Scale （HAMD） and Wechsler memory scale （WMS） and also compared with 42 cases of healthy subject （control group）. Results： （1）Compared with the control group, the long-term memory, short-term memory, immediate memory increased significantly and MQ increased significantly after 12 weeks treatment in first-episode depressions given QSFK and fluoxetine （P〈0.05）. Compared with the control group, no difference was found on the long-term memory （P〉0.05）, the short-term memory were decreased significantly （except the touch factor, P〈0.05）, immediate memory and MQ were decreased significantly in the postpartum depression group （P〈0.05）. （2） Compared with the postpartum depression group, the long-term memory were decreased significantly （P〈0.05）, and pictures and recognition factor in the short-term memory increased significantly （P〈0.05）, and no difference was found on association, touch and understanding factor in the short-term memory （P〈0.05）, and no difference was found on immediate memory and MQ （P〈0.05）. Conclusion： Both postpartum and non postpartum depression presented a decline defect on the memory function, but the damaged components were different, the impaired memory function in the postpartum depressions was a kind of functional damage.