麻疹疫苗最佳免疫月龄的研究

The Study of the Best Immunization Time of Measles Vaccine for Newborns

对 5 8对 2 5～ 30岁产妇及其婴儿的麻疹抗体的研究表明 ,5 8对母婴中有 5 1对母婴麻疹抗体滴度相同 ,7对不同 ,但只相差 1个滴度 ,且两者抗体均处于低水平 ,说明母婴抗体间有密切关系。通过对胎传抗体追踪观察发现 ,新生儿抗体水平不高 ,3月龄时抗体阳性率已降至 48 3% ,6月龄和 8月龄时分别降至 19 0 %和 15 0 % ,6月龄和 8月龄婴儿接种麻疹疫苗后免疫成功率分别为 84 5 %和 85 0 % ,因此可考虑将麻疹疫苗初免提前到

Through the study of measles antibody level of puerpera and their newborns, it found that the measles antibody level in most mature women was low. Measles antibody level of 51 mothers and their newborns were the same and, 7 pairs were different by one titer. It meant that measles antibody level between mothers and their newborns was closely related, therefore newborn's antibody level can be raised by vaccination to mature women. Through detection of maternal transferred measles antibody level of different month old infants, it revealed that measles antibody positive rate in newborns was not high and it reduced to 48.3% at 3 months old, to 19% at 6 months old, to 15% at 8 months old, which afforded nearly no protection for the infants. When vaccinating 6 month old infants and 8 month old infants, the immunizing successful rates of them were 84.4% and 85.00% respectively and the measles antibody distribution of them showed no difference. Authors suggest that it should be better to change the first vaccination of measles vaccine from 8 months old to 6 months old, and revaccinated at the age of 18 months old. It also should be considered to be vaccinated again for mature women.