狼疮肾炎遗传学研究现状

Current status on genetic research of lupus nephritis

狼疮肾炎是系统性红斑狼疮重要的疾病表型。大量研究提示,遗传因素参与狼疮肾炎的发病及进展。群体遗传学研究数据提示非裔、亚裔人群比欧裔人群发病风险高。而新近基于全基因组关联分析的研究更提示多个基因的遗传变异参与狼疮肾炎的发病,这为进一步探讨发病机制提供了重要的线索。该文简要介绍狼疮肾炎的遗传学研究现状,包括目前研究的成果及不足,以期为未来深化发病机制研究、促进个体化诊治提供依据。

Lupus nephritis is one of the most serious manifestations of systemic lupus erythematosis （SLE） and also an im- portant predictor of poor outcome. Up to date, the clear etiology is still obscure. Data from a great of amount of studies sup- port an important role of genetics in disease occurrence and progression. Genetic ancestry studies indicate that African and Asian genetic ancestries are associated with an increased risk of lupus nephritis as compared to European ancestry. In addi- tion, based on the data from genome-wide association studies conducted in SLE, several novel genetic associations have been observed in lupus nephritis,providing key clues for further elucidating pathogenesis of this phenotype. Ongoing refined ge- netic studies centering lupus nephritis are underway. In this review,we will discuss highlights as well as drawbacks of these studies, hoping to contribute more to pathogenesis research and individualized treatment of lupus nephritis.