Plexin A1在直肠癌中的表达及其意义被引量：1

Theexpression and clinical significance of Plexin A1 in rectal cancer

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摘要目的研究Plexin A1在直肠癌中的表达及其与淋巴结转移的关系。方法采用免疫组化和RT-PCR方法检测67例直肠癌组织和45例正常直肠黏膜组织中Plexin A1的表达,并分析Plexin A1与患者临床病理特征的关系。结果 RTPCR和免疫组织化学结果显示,直肠癌组织中Plexin A1的mRNA表达明显高于癌旁的直肠正常黏膜组织(P<0.05)。在直肠癌患者中Plexin A1的表达强度与直肠癌的微血管密度(Microvessel density,MVD)、淋巴结转移(P<0.05)和Dukes分期(P<0.05)具有相关性。结论 Plexin A1在直肠癌组织中高表达,可能参与了直肠癌的发生发展和血管生成过程,检测Plexin A1的表达能够作为直肠癌的诊断和转移的依据。 Objective T0 discuss the expression of Plexin A1 in rectal cancer and its relationship with clinical and pathogical factors.Methods：Immunohistochemistry and RT-PCR was performed to detect expression of Plexin A1 in 67 rectal cancer samples and analyzed the relationship between the expression of Plexin A1 and the clinicpathological characteristics of patients.Results：RT-PCR and immunohistochem istry results revealed that Plexin A1 expression in the rectal cancer tissue was significantly higher than normal mucosa of rectum tissue （P ＜0.05）.The expression of Plexin A1 was closely related to microvessel density （MVD）,lymph node metastasis （P ＜0.05） and Dukes staging （P ＜0.05） in patients with rectal cancer.Conclusion：The expression of Plexin A1 in rectal cancer tissue was associated with tumor angiogenesis.Monitoring the expression of Plexin A1 can predict rectal cancer metastasis.

作者曾建成黄玉梅陈凤玲

机构地区深圳市宝安区西乡人民医院肛肠外科

出处《结直肠肛门外科》 2013年第5期307-310,共4页 Journal of Colorectal & Anal Surgery

关键词直肠癌 PLEXIN A1 MVD Rectal cancer Plexin A1 MVD

分类号 R735.37 [医药卫生—肿瘤]

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