冠心病患者炎性因子的变化及其与血清视黄醇结合蛋白4水平的相关性研究

The Correlation Research between Retinol Binding Protein 4 and Inflammatory Cytokines of Patients with Coronary Heart Disease

目的探讨冠心病患者血清高敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、MCP-1与视黄醇结合蛋白4(RBP4)的相关性。方法分别收集健康组、动脉粥样硬化组、CHD组患者,检测其空腹血清RBP4、hs-CRP、IL-6、MCP-1水平。结果与健康组相比,AS组、CHD组患者血清RBP4、hs-CRP、IL-6、MCP-1含量明显升高(P<0.05或P<0.01);相关性分析显示AS组、CHD组患者血清RBP4与炎性因子hs-CRP、IL-6、MCP-1呈正相关。结论 RBP4参与了动脉粥样硬化的炎性反应过程,其可能通过多种途径直接或间接地参与冠心病的发生发展。

Objective To discuss the relationship between the high sensitivity C-reactive protein（hs-CRP）,interleukin-6,monocyte chemoattractant protein-1 and Retinol binding protein 4 of patients with coronary heart disease. Methods The healthy group, AS group and CHD group were collected. The serum level of RBP4, hs-CRP, IL-6, MCP-1 was measured.Results Compared with the healthy group, The serum level of RBP4 and hs-CRP, IL-6. MCP-1 were higher in AS and CHD group that in healthy group （P＆lt;0.05 or P＆lt;0.01）.Correlation analysis showed that The serum level of RBP4 and hs-CRP,IL-6.MCP-1 were signiifeantly positive correlation in AS and CHD group. Conclusion RBP4 involve the Inlfammatory reaction process of Atherosclerosis, which could partake the the occurrence of coronary heart disease development through many ways directly or indirectly.