摘要
微流体系统作为一种可对流体进行精密控制、操作与检测的技术,其发展为细胞体外培养提供了新的平台,而且可与生物传感器结合构成微流体传感测试系统,大大提高细胞传感检测的精确性、一致性和稳定性。在微系统设计与制造的基础上,提出了一种新型微流体系统结构,应用COMSOL软件建立了微流体系统模型,通过对其流动特性的分析对比,优化了系统结构,系统地研究了其对细胞培养与检测的影响。结果表明:该结构既能实现细胞的长期培养;又能通过精确的微流控制,结合生物传感器,对不同时期或不同病态的细胞进行实时检测和分析。该研究对医用药物测试芯片与微流传感测试系统有着重要的意义。
Microfluidic system as a kind of technology which can deal with fluids with precise control, manipulation and testing,its development provides a new platform for cells cultivation in vitro and it can constitute microfluidics sensing and test system by combining with biosensor,which can greatly improve the accuracy, consistency and stability of cell sensing test.On the basis of microsystem design and fabrication,a novel microfluidic system structure is proposed,and its model is built with the COMSOL software.By analyzing and comparing its flow characteristics,system structure is optimized,and the influences on cell cultivation and test are investigated systematically.Result indicates that,this structure can not only achieve long-term cultivation of cells, but also can real-time detect and analyze cells in different periods or different physiological states by precise control,combine with biosensors.The research has great signficance in medical drug test chip and microfluidics sensing and test system.
出处
《传感器与微系统》
CSCD
北大核心
2014年第3期114-117,共4页
Transducer and Microsystem Technologies
基金
国家自然科学青年基金资助项目(51105267)
教育部高等学校博士学科点基金资助项目(20111402120007)
中国博士后科学基金面上资助项目(2011M500542)
山西省回国留学人员科技活动项目择优资助项目(2011lX10)
关键词
微机电系统
微流体
传感测试平台
流动特性
细胞培养
MEMS
microfluidic
sensing and test platform
flow characteristics
cell cultivation
