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β-防御素-2在感染性疾病中应用的研究进展

Application of beta-defensin-2 in infectious diseases
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摘要 人体β--防御素-2（human-β-defensin-2，HBD12）是一种可诱生型小分子抗菌肽。近年来的研究表明，HBD-2不仅对普通病原微生物具有抗菌作用，还对目前日益增多的多重耐药菌具有一定的抗菌优势。HBD-2在感染、炎症中的特性使其在某些疾病的发生、发展与转归过程中起到一定的预后评估作用，并具有某种生物标记物的潜在价值。 Human β-defensin-2 （HBD-2） is an inducible small cationic antimicrobial peptide. It has been shown that HBD-2 elicits antimicrobial effects on multidrug-resistant pathogens in addition to many normal pathogens. HBD-2 also has certain effects on prognosis of some infectious diseases, furthermore,it is probably to be used as an biomarker in the occurrence and development of the infectious disease.
作者 李婷 刘松
机构地区 首都医科大学附属北京友谊医院呼吸内科
出处 《国际呼吸杂志》 2014年第4期286-289,共4页 International Journal of Respiration
关键词 Β-防御素 感染 应用 生物标记物 β--defensin Infection Application Biomarker
分类号 R51 [医药卫生—内科学]
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参考文献28

  • 1Hiemstra PS. The role of epithelial beta-defensins and cathelicidins in host defense of the lung[J].EXPERIMENTAL LUNG RESEARCH,2007.537-542.
  • 2何丽蓉,刘松,贺正一.人β-防御素-2在肺部炎性疾病的研究进展[J].国际呼吸杂志,2009,29(9):569-572. 被引量：2
  • 3Schr(o)der JM,Harder J. Human beta-defensin-2[J].International Journal of Biochemistry & Cell Biology,1999.645-651.
  • 4Chen Z,Wang D,Cong Y. Recombinant antimicrobial peptide hPAB-β expressed in Pichia pastoris,a potential agent active againstmethicillin-resistant Staphylococcus aureus[J].Applied Microbiology and Biotechnology,2011.281-291.
  • 5Wang D,Chen Z,Hu Z. A recombinant antimicrobial peptide inhibits the growth of oxacillin-induced L-forms of Staphylococcus aureus[J].International Journal of Antimicrobial Agents,2011.177-178.
  • 6Corrales-Garcia L,Ortiz E,Casta(n)eda-Delgado J. Bacterial expression and antibiotic activities of recombinant variants of human β-defensins on pathogenicbacteria and M.tuberculosis[J].Protein Expression and Purification,2013.33-43.
  • 7Harder J,Bartels J,Christophers E. A peptide antibiotic from human skin[J].NATURE,1997.861.
  • 8García JR,Jaumann F,Schulz S. Identification of a novel,multifunctional beta defensin (human beta-defensin 3)with specific antimicrobial activity.Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction[J].Cell and Tissue Research,2001.257-264.
  • 9Harder J,Bartels J,Christophers E. Isolation and characterization of human beta-defensin-3,a novel human inducible peptide antibiotic[J].Journal of Biological Chemistry,2001.5707-5713.
  • 10Jung S,Mysliwy J,Spudy B. Human beta-defensin 2 and beta-defensin 3 chimeric peptides reveal the structural basis of the pathogenspecificity of their parent molecules[J].ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2011.954-960.

二级参考文献26

  • 1武庆平,刘萍,姚尚龙.β-防御素-2在机械通气相关性肺炎发病机制中的作用[J].华中科技大学学报（医学版）,2005,34(5):608-611. 被引量：5
  • 2张舒,黄宁,赵新宇,王青松,杨洋,成勇,鞠辉明,熊文碧,欧珍蓉,吴琦,王伯瑶.β防御素2转基因小鼠抗金黄色葡萄球菌感染的研究[J].中华医学杂志,2006,86(26):1834-1836. 被引量：3
  • 3熊盛道,兰芬,许淑云,周世新.人β-防御素-2在慢性阻塞性肺疾病患者诱导痰中的表达[J].中国现代医学杂志,2006,16(20):3069-3072. 被引量：7
  • 4Braff MH, Gallo RL. Antimierobial peptides: an essential component of the skindefensive barrier. Curr Top Microbiol Immunol, 2006,306 : 91-110.
  • 5Ganz T. Defensins:antimicrodial peptides of innate immunity. Nat Rev Immunol, 2003,3 : 710-720.
  • 6Yang D, Biragya A, Hoover DM, et al. Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense. Annu Rev Immunol, 2004, 22: 181-215
  • 7Pazgier M, Hoover DM, Yang D, et al. Human beta-defensins. Cell Mol Life Sci, 2006,63 : 1294-1313.
  • 8Linzmeier RM, Ganz T. Human defensin gene copy number polymorphisms: compre-hensive analysis of independent variation in alpha-and beta-defensin regions at 8p22-p23. Genomies, 2005,86 : 423-430.
  • 9Wehkamp K, Schwichtenberg L, Schroder JM, et al. Pseudomonas aeruginosa-and IL-lbeta-mediated induction of human beta-defensin-2 in keratinocytes is controlled by NF- kappaB and AP-1. J Invest Dermatol, 2006,126 : 121-127.
  • 10Mineshiba J, Myokia F, Mineshiba F, et al. Transcriptional regulation of beta-defensin-2 by lipopolysaccharide in cultured human cervical carcinoma (HeLa) cells. FEMS Immunol Med Microbiol, 2005,45 .. 37-44.

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国际呼吸杂志
2014年 第4期

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