乳腺癌患者人表皮生长因子受体-2表达与肿块大小及淋巴结转移的关系

Relationship between the expression of CerbB-2 and tumor size,lymph node metastasis in breast cancer

目的：探讨乳腺癌患者人表皮生长因子受体-2（CerbB-2）表达与肿块大小及淋巴结转移的关系。方法采用免疫组织化学法（SP）检测80例乳腺癌患者CerbB-2表达情况，并分析其与肿块大小及淋巴结转移的关系。结果68％（45例）乳腺癌患者CerbB-2阳性表达，CerbB-2在肿块＜2 cm组，2～5 cm组，＞5 cm组阳性表达率分别为44％（8例）、59％（32例）、62％（5例）。CerbB-2阳性表达与肿块大小无关（ P＞0.05）。49％的乳腺癌患者有淋巴结转移，CerbB-2在淋巴结转移者中的阳性表达率为77％，CerbB-2阳性表达与淋巴结转移有关（P＜0.05）。结论 CerbB-2阳性表达与肿块大小无关，CerbB-2阳性表达者易出现淋巴结转移。

Objective To explore the relationship between the expression of CerbB-2 and t tumor size , lymph node metastasis in breast cancer .Methods The expression of C-erbB2 in 80 cases with breast cancer was detected with immunohistochemical technique （SP） ,then the relationship between the expression of CerbB-2 and tumor size ,lymph node metastasis was analyzed .Results Positive expression of CerbB-2 was found in 68% cases of breast cancer .The positive rates of CerbBof CerbB-2 were 44% ,59% and 62% in three different tumor size groups ,respectively .There was no significant association between CerbB-2 expression and tumor size （P＆gt;0.05） . Lymph node metastasis was found in 49% cases of breast cancer .The positive rates of CerbB-2 were 77% in cases with lymph node metastasis .Expression of CerbB-2 was correlated with lymph node metastasis （P＆lt;0.05） .Con-clusion There was no significant association between the expression of CerbB-2 and tumor size .Lymph node me-tastasis is easy to develop in the patients of CerbB-2 positive expression .