母婴垂直传播乙型肝炎病毒的阻断研究

A study on the Interruption of HBV transmission from mother to newborn Infants

目的 探讨乙肝免疫球蛋白（ＨＢＩｇ）和乙肝疫苗接种阻断乙型肝炎病毒（ＨＢＶ）母婴垂直传播对新生儿的保护作用。方法 对母亲为大三阳的新生儿肌注ＨＢＩｇ和乙肝疫苗（Ｉ组），母亲为小三阳的新生儿仅肌注乙肝疫苗（Ⅱ组），出生后 ６、９、１２个月检测 ＨＢｓＡｇ和ＨＢｓＡｂ。结果 Ｉ组新生儿在生后 １２个月 ＨＢｓＡｇ、ＨＢｓＡｂ阳性率分别为 １４． ２９％和 ７１． ４２％，Ⅱ组 ＨＢｓＡｇ、ＨＢｓＡｂ阳性率分别为 ０． ０％和 ８６． ６７％。结论 宫内感染是乙肝疫苗接种失败的主要原因。

Objective To investigate the effects of HBIg and hepatitis B vaccine on the prevention of HBV transmission from mother to newborn infants. Methods Newborn infants whose mothers were HBsAg (+ ), HBeAg(+) and HBcAb(+) were treated with HBIg and hepatitis B vaccine (Group I),while the newborn infants whose mother were HBsAg(+),HBeAb(+) and HBcAb(+ ) were injected hepatitis B vaccine only (Group Ⅱ). HBsAg and HBsAb were detected at 6, 9, 12 month after birth. Results In group I,Infants' HBsAg and HBsAb positive rate were 14. 29% and 71. 42% respectively, while in group Ⅱ,were 0. 0% and 86. 67%. Conclusion Intrauterine infection is responsible to the failing inoculation of hepatitis B vaccine.