肌萎缩侧索硬化诊断及治疗进展

Advances in Diagnosis and Treatment of Amyotrophic Lateral Sclerosis

肌萎缩侧索硬化(ALS) 是一种累及上下运动神经元的进展性神经系统变性病,临床怀疑该病可遵循近期已建立的规范和国际标准,以免漏诊和误诊。根据各种学说发展了谷氨酸拮抗剂、自由基损伤的保护刑或神经营养因子治疗。目前唯一确认利鲁生(力如太)对阻止该病进展有一定效果,其他治疗正在试验中。

Amyotrophic lat -eral sclerosis (ALS) is a progressive degeneration of upper and lower motor neurons. Patients with findings suggestive of ALS are accorded with defined diagnostic criteria. Recent theories on the pathogenesis of motor neuron disease have resulted in new putative therapies, which include treatment with various neurotrophic factors, antioxidants and anti -excitotoxicity agents. Clinical studies have now provided the first agent, riluzole, that reproducibly alters the course of amyotrophic lateral sclerosis.