甲基强的松龙脉冲疗法对高度或完全性房室传导阻滞治疗的临床研究

Clinical Observation of Impulse Treatment with Methylprednisolone in High or Complete Atrioventricilar Block

目的:探讨甲基强的松龙脉冲疗法对高度或完全性房室传导阻滞(AVB)重症期病例的临床应用价值,方法;对13例高度或完全性AVB重症期在常规治疗的基础上加用甲基强的松龙500mg/天静脉给药,观察其用药前后症状、心率、心律变化 并与12例加用地塞米松和8例单纯用654-2进行对照.结果:甲基强的松龙脉冲治疗后平均心率(74.8次/分)比治疗前(46.2次/分)显著提高P<0.05.总有效率(79.92%)明显高于加用地塞米松(58.33%)和单纯用654-2(37.50%),p<0.05.结论:甲基强的松龙脉冲疗法对高度或完全性AVB具有较好的临床疗效和毒副作用少.对伴有严重肝。

Purpose: To evaluate the clinical significance of impulse treatment with methlprednisolone in high atrioventricular block or complete atrioventricular block (AVB) . Methods: 13 patients with high AVB or complete AVB in acute phase were treated with 654 - 2 plus methylprednisolone 500mg/day venous drip for 1-2 days. We observed symptoms, heart rate and heart rhythm responese in pretreatment and posttreatment. Compare with 654-2 alone (8 patients) and treatment with 654 - 2 plus dexamethasone (12 patients). Results: It showed that impulse treatment with methylprednisolone was remarkable difference between pretreatment and postreatment in average heatr rate (p<0.05) .The total effective rate (79.92%) was significantly higher than that in treatment with 654-2 alone(37.5%) and that in treatment with 654-2 plus dexamethasone (58.33%) (p<0.05).Conclusions: The results of this study indicate that impulse treatment with methylprednisolone in high AVB or complete AVB is safe and effective. It does not cause any adverse ernal or metabolic effects.