摘要
苯唑西林酶OXA-48是一种D类碳青霉烯酶,近年来在肠杆菌科中报道日益增多。该酶对青霉素类水解能力很强,对碳青霉烯类药物活性较弱,酶活性不能被β-内酰胺酶抑制剂抑制。blaOXA-48基因上下游分别有一插入序列IS1999,共同组成转座子Tn1999。大多数菌株中,blaOXA-48基因位于一个可转移并且不携带其他耐药基因的62kb的质粒上,因此可以在细菌间广泛传播。PCR技术是检测菌株是否携带blaOXA-48基因的金标准。
OXA48 carbapenemase belongs to class D β-lactamase and is increasingly reported in enterobacteriaceae. This enzyme hydrolyzes penicillins significantly whereas hydrolyzes carbapenems at a very low level , and it is not susceptible to β-lactamase inhibitors. The blaOXA-48 was part of a composite transposon named Tn1999 and made of two copies of IS 1999 bracketing this gene. The current spread of the blaOXA-48 gene is mostly linked to the dissemination of a self-transferable plasmid of 62 kb that does not carry any additional resistance gene. Therefore, it can spread widely among bacteria. The technique of PCR remain the gold standard for the identification of isolates earring blaoXA-48 gene.
出处
《疾病监测》
CAS
2014年第1期79-82,共4页
Disease Surveillance
