P33^(ING1)在胃癌组织中的表达及其意义

Expression of P33^(ING1) in stomach cancer and its clinical significance

目的 :探讨 P33ING1表达在胃癌发生、发展过程中的病理生物学及临床意义。方法 :应用免疫组化 En Vision法 ,分别检测了原发性胃癌 (71例 )、胃粘膜不典型增生 (12例 )、正常胃粘膜或慢性胃炎粘膜 (18例 )组织中 P33ING1的表达 ,以及 P5 3和Bcl- 2在胃癌组织中的表达情况。结果 :胃粘膜不典型增生组及对照组 (正常胃粘膜或慢性胃炎粘膜 ) P33ING1均呈阳性表达 ,胃癌组织 P33ING1表达率仅为 6 2 .0 % (4 4/ 71) ,显著低于前两组 (P<0 .0 1)。胃癌组织中 P33ING1表达与肿瘤的浸润、淋巴结的转移及分化有关 (P<0 .0 1) ;P5 3表达与肿瘤大小、浸润、淋巴结转移有关 (P<0 .0 1) ;Bcl- 2与肿瘤的淋巴结转移及分化有关 (P<0 .0 5 )。 P33ING1 与 P5 3在胃癌组织中的表达有相关性 (P<0 .0 5 ) ,与 Bcl- 2则无相关性。结论 :P33ING1 在胃癌组织中表达下降 ,对胃癌发生、发展可能起重要作用。同时检测 P33ING1 与 P5 3的表达水平 。

Objective:To discuss the pathological relationship between P33 ING1 and stomach cancer and its clinical significance. Methods: In 71 cases of stomach cancer specimen, twelve cases of gastric mucous membrane atypical hyperplasia tissues and 18 cases of normal gastric mucous membrane tissue(as control),the expression of P33 ING1 were detected by EnVision immunohistochemical method,while the expression of P53 and Bcl 2 in stomach cancer were also detected. Results: P33 ING1 expression in mucous membrane atypical hyperplasia group and control group was positive, the expression in stomach cancer group was extremely low(62.0%,44/71), significantly different from the other 2 groups( P <0.01).P33 ING1 expression in stomach cancer was related to the tumor growth, lymph node metastasis and tumor polarization ( P <0.01), P53 expression was related to tumor size, growth and lymph node metastasis ( P <0.01). Bcl 2 expression was related to lymph node metatasis and tumor polarization.The expression of P33 ING1 was related to that of P53 in stomach cancer( P <0.05),while had no relation with that of Bcl 2.Conclusion:P33 ING1 may play an important role in the occurrance and development of stomach cancer.It's very important to detect the expression of P33 ING1 and P53 simultaneously.