摘要
目的 研究内毒素对孕鼠蛋白尿的影响 ,并探讨其发生机制。方法 在鼠妊娠的第 14天 ,沿尾静脉分别注入内毒素 (1.0 μg/ kg) 13只 ,注入生理盐水 (1.0 m L/ kg) 7只。测尿蛋白含量。结果 孕鼠中内毒素注射组尿蛋白含量明显较生理盐水组增高 (P<0 .0 1)。
Objective To study the effect of endotoxin on pregnant rat′s urinary albumin excretion and look for its mechanism.Method Through rat′s tail vein endotoxin (1 0 μg/kg,n=13) or saline solution (1 0 mL/kg,n=7) was infused on the day 14 of pregnancy.Albuminuria was measured in these rats.Results A significant urinary albumin excretion (P<0 01) was observed in endotoxin treated pregnant animals,in contrast to control pregnant rats receiving saline solution.ConclusionEndotoxin may induce pregnant rat′s renal injury,and make significantly increased albumin excretion in the animals.
出处
《山西医药杂志》
CAS
2001年第1期21-22,共2页
Shanxi Medical Journal
基金
太原市科技启明星资助项目! (982 0 72 )
