期刊文献+

Acquired Cardiomyopathy Caused by Cardiac Tsc1 Deficiency

Acquired Cardiomyopathy Caused by Cardiac Tsc1 Deficiency
原文传递
导出
摘要 Cardiomyopathies are myocardial disorders with enlarged, thick, or rigid cardiac muscles. Because no effective treatment is available to prevent the deterioration of the myocardium function, the prognosis of cardiomyopathy is usually poor. Cardiomyopathies can be inherited or acquired. A number of genes associated with inherited cardiomyopathy, such as the genes encoding for sarcomeric, cytoskeletal, Cardiomyopathies are myocardial disorders with enlarged, thick, or rigid cardiac muscles. Because no effective treatment is available to prevent the deterioration of the myocardium function, the prognosis of cardiomyopathy is usually poor. Cardiomyopathies can be inherited or acquired. A number of genes associated with inherited cardiomyopathy, such as the genes encoding for sarcomeric, cytoskeletal,
出处 《Journal of Genetics and Genomics》 SCIE CAS CSCD 2014年第2期73-77,共5页 遗传学报(英文版)
基金 supported by the National Natural Science Foundation of China (No. 81270288) the Chinese Ministry of Science and Technology (No. 2011CB965002)
  • 相关文献

参考文献21

  • 1Cheadle,J.P,Reeve,M.P,Sampson,J.R,Kwiatkowski,D.J. Molecular genetic advances in tuberous sclerosis[J].{H}Human Genetics,2000.97-114.
  • 2Crone,S.A,Zhao,Y.Y,Fan,L,Gu,Y Minamisawa,S Liu,Y Peterson,K.L Chen,J Kahn,R Condorelli,G Ross Jr J Chien,K.R Lee,K.F. ErbB2 is essential in the prevention of dilated cardiomyopathy[J].{H}Nature Medicine,2002.459-465.
  • 3Dazert,E,Hall,M.N. mTOR signaling in disease[J].{H}Current Opinion in Cell Biology,2011.744-755.
  • 4Frey,N,Katus,H.A,Olson,E.N,Hill,J.A. Hypertrophy of the heart:a new therapeutic target[J].{H}CIRCULATION,2004.1580-1589.
  • 5Hershberger,R.E,Cowan,J,Morales,A,Siegfried,J.D. Progress with genetic cardiomyopathies:screening,counseling,and testing in dilated,hypertrophic,and arrhythmogenic right ventricular dysplasia/cardiomyopathy[J].Circ Heart Fail,2009.253-261.
  • 6Hershberger,R.E,Morales,A,Siegfried,J.D. Clinical and genetic issues in dilated cardiomyopathy:a review for genetics professionals[J].Genet Med,2010.655-667.
  • 7Kobayashi,T,Minowa,O,Sugitani,Y,Takai,S Mitani,H Kobayashi,E Noda,T Hino,O. A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar,but not identical to,those caused by Tsc2 mutation in mice[J].{H}Proceedings of the National Academy of Sciences(USA),2001.8762-8767.
  • 8Kwiatkowski,D.J,Zhang,H,Bandura,J.L,Heiberger,K.M Glogauer,M E1-Hashemite,N Onda,H. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas,and upregulation of p70S6 kinase activity in Tsc1 null cells[J].{H}Human Molecular Genetics,2002.525-534.
  • 9Malhowski,A.J,Hira,H,Bashiruddin,S,Warburton,R Goto,J Robert,B Kwiatkowski,D.J Finlay,G.A. Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin[J].{H}Human Molecular Genetics,2011.1290-1305.
  • 10Ma,A,Wang,L,Gao,Y,Chang,Z Peng,H Zeng,N Gui,Y.S Tian,X Li,X Cai,B Zhang,H Xu,K.F. Tsc1 deficiency-mediated mTOR hyperactivation in vascular endothelial cells causes angiogenesis defects and embryonic lethality[J].{H}Human Molecular Genetics,2013.693-705.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部