齐拉西酮与奥氮平治疗精神分裂症的疗效和安全性Meta分析

Efficacy and safety of ziprasidone and olanzapine in treatment of schizophrenia:a meta analysis

目的评价齐拉西酮与奥氮平治疗精神分裂症对照研究期间疗效和安全性的差异。方法应用循证医学方法对符合标准的19项研究进行分析,评价齐拉西酮与奥氮平治疗精神分裂症过程中有效率、治愈率、治疗后量表评分及不良反应等的差异。结果齐拉西酮与奥氮平治疗精神分裂症的有效率、治愈率和治疗后量表评分均无统计学差异(均P>0.05);不良反应齐拉西酮组多见失眠、锥体外系反应、心电图异常,奥氮平组多见嗜睡、体重增加、食欲增加、血糖增加,两组比较均有统计学差异(均P<0 05)。结论齐拉西酮和奥氮平均是治疗精神分裂症的合适药物,治疗效果类似,但是其不良反应存在统计学差异。

Objective To compare the efficacy and safety of ziprasidone with olanzapine in treatment of schizophrenia. Methods Nineteen studies were included and analyzed. The differences in efficiency, cure rate, scale score and adverse re-actions for treatment of schizophrenia between ziprasidone and olanzapine were evaluated. Results There were no differ-ences in efficiency, cure rate, scale score for treatment of schizophrenia between ziprasidone and olanzapine. The adverse re-actions of ziprasidone were mainly insomnia, extrapyramidal symptoms, abnormal electrocardiogram; and those of olanzapine were mainly lethargy, weight gain, increased appetite, increased blood sugar; the differences were statistical y significant. Conclusion Ziprasidone and olanzapine both are effective drugs for schizophrenia with a similar efficacy and different adverse reactions.