1,4-苯并二噁烷新木脂素Eusiderin G类似物的合成

Synthesis of 1,4-Benzodioxane Type Neolignan Eusiderin G Analog

为了寻找新的抗高血压活性的化合物 ,合成了 1 ,4 -苯并二口恶烷新木脂素 Eusiderin G类似物 .合成反应的关键步骤是在强酸性离子交换树脂催化下 ,分子内的醇羟基与酚羟基之间发生脱水反应 ,闭环形成 1 ,4 -苯并二口恶烷骨架化合物 .

In order to search for new antihypertensive agent,1,4-benzodioxane type neolignan Eusiderin G analog was synthesized,and we think that the cyclization of a dihydroxy intermediate under catalysis of strong acid ion exchange resin to give 1,4-benzodioxane sketch is the key step during the synthesing process.