基于羟基磷灰石的丹酚酸组分磷脂复合物共沉淀物的制备研究

Studies on hydroxyapatite applicatied in coprecipitate of total salvianolic acids phospholipid complex

该实验旨在制备丹酚酸组分磷脂复合物的羟基磷灰石(HA)共沉淀物,以提高药物的体外溶出,同时改善丹酚酸组分磷脂复合物的粉体学性质。首先采用溶剂法制备共沉淀物,以丹酚酸组分中的丹酚酸B和丹参素为指标成分考察其体外溶出,同时对其进行粉体学性质的考察,并利用DSC,XRD,FTIR等表征手段对其结构特征进行分析研究。结果可得丹酚酸组分磷脂复合物与羟基磷灰石按1∶2制备的共沉淀物的体外溶出效果较好,60 min时药物的体外累积溶出率达到90%以上;粉体学性质考察结果表明该共沉淀物流动性良好,吸湿性低,粉体学性质得到了较大的改善,微观结构的表征分析表明药物仍旧以非晶形式存在。该实验的制备工艺简单可行,具有实际应用价值。

The purpose of this research was to prepare total salvianolic acids-phytosome-HA coprecipitate to improve drug dissolution and its micromeritic properties. Firstly, the coprecipitate was prepared by solvent method and in vitro dissolution of tripterine was performed with the salvianolic acid B and danshensu as criteria.At the same time, the micromeritic properties was characterizated, the structure of samples was characterized by TEM,DSC,XRD and FTIR.Results showed that when the ratio of drug to HA was 1：2, it had a better dissolution, the accumulative drug-release percent in vitro at 60 min was over 90%. At the same time, it has good liquidityand low moisture absorption.Its micromeritic properties have improved. It is proved that the drug still existed amorphously by microstructure analysis. The preparation process is simple and feasible,it has practical value.