64例肺部感染住院患者抗菌药物临床应用分析

Analysis on Clinical Application of Antibacterial Agents in 64 Inpatients with Pulmonary Infection

目的调查医院肺部感染住院患者抗菌药物临床使用现状,为临床合理用药提供依据。方法采用回顾性调查方法,随机抽取2011年1月至12月医院呼吸科出院归档肺部感染患者病历64份,对用药品种、用药时间、联合用药、细菌学培养等情况进行统计分析。结果 64例肺部感染患者全部使用了抗菌药物,使用频度最高的药物为盐酸莫西沙星氯化钠注射液及盐酸莫西沙星片;二联用药最多63例次(占74.12%),单一用药10例次,三联用药12例次;联合使用频度最高的是喹诺酮类联用第2代和第3代头孢菌素,占65.08%;平均用药疗程为9.4 d;细菌培养送检率为84.38%;使用的27个抗菌药物品种中有头孢呋辛酯片、注射用头孢哌酮钠舒巴坦钠及注射用头孢米诺钠等7个品种的药物利用指数(DUI)>1。结论医院肺部感染住院患者抗菌药物使用基本合理,但仍存在不足,有待进一步强化合理用药意识,按照抗菌药物临床应用指导原则加强监管力度。

Objective To investigate the eurrent situation of the clinical application of antibacterial agents in the inpatients with lung infections so as to provide the basis for rational drug use in clinic. Methods By adopting the retrospective analysis,64 cases of the pulmonary infection medical records in the respiration department of our hospital from January to December 2011 were randomly ex- tracted and performed the statistical analysis on the drug varieties,duration of medication,drug combination,hacterial cuhure,etc. Results All 64 cases used the antibacterial drugs. Moxifloxacin Hydrochloride and Sodium Chloride Injection and Moxifloxacin Hydrochloride Tablet had the highest use frequency; the 2-drug combination use had 63 cases-times and accounted for 74. 12%, 10 case-times were single drug use and 12 case-times were 3-drug combination use;the highest use frequency of the combination use was Quinolones combined with the second generation cephalosporin and the third generation cephalosporin （accounting for 65.08% ）;the av- erage course of medication was 9.4 d;the bacterial culture rate was 84.38% ;among 27 varieties of used antibacterial drugs,the drug utility index（DUI） in 7 varieties of antibacterial drug Ceturoxime Axetil Tablets,Cefoperazone Sodium and Sulbactam Sodium for Injec- tion and Cefminox Sodium Injection was 〉 1. Conclusion The application of antibacterial drugs in the inpatients with puhnonary infec- tion in our hospital is basically reasonable,but there are still insufficient,which needs to further intensify the awareness of rational drug use and strengthen the supervision aecording to the guiding principles of clinical use of antibacterial drugs