烧伤患者早期合并心肌细胞及心功能损害的临床监测

Clinical Monitoring on Early Combined Damage of Myocardial Cell and Cardiac Function in Burn Patients

目的:通过观察烧伤患者早期血清心型脂肪酸结合蛋白(h-FABP)和N末端B型钠尿肽原(NT-proBNP)水平变化,探讨其对早期合并心肌细胞及心功能损害的临床监测价值。方法:选取本院49例合并心肌细胞损害患者(损害组)和50例健康对照组作为研究对象。血清h-FABP检测采用双抗体夹心酶联免疫(ELISA)一步法,血清NT-proBNP检测采用电化学发光免疫分析(ECLIA)法,观察患者治疗前后血清NT-proBNP和h-FABP的水平变化及两者间的相关性分析。结果:烧伤患者治疗前血清h-FABP阳性率(80.3%)明显高于NT-proBNP(50.8%)(P<0.01)。损害组患者治疗前血清NT-proBNP和h-FABP水平均明显高于对照组(P<0.01),治疗后水平明显下降(P<0.01),与对照组比较差异无统计学意义(P>0.05),心电图(ECG)及心功能检测也无异常表现。血清NT-proBNP与h-FABP呈显著正相关(r=0.629,P<0.01),相关性良好。结论:联合检测血清NT-proBNP和h-FABP水平,可早期诊断烧伤患者合并心肌细胞及心功能损害,也可用于临床疗效的观察。

Objective：To explore the clinical value of h-FABP and NT-proBNP in monitoring early combined damages of myocardial cells and cardiac function by observing change of serum h-FABP and NT-proBNP level in early burn patients.Method：A total of 49 cases with myocardial cell damage（the damage group）and 50 healthy people（the control group）were selected as the research objects.Serum h-FABP was detected by ELISA one-step,and serum NT-proBNP was inspected by ECLIA method.Result：The positive rate of serum h-FABP in burn patients（80.3%）before the treatment was significantly higher than that of NT-proBNP（50.8%）（P〈0.01）.The level of serum NT-proBNP and h-FABP in the damage group before treatment were significantly higher than that in the control group（P〈0.01）,and that of the two groups after treatment were significantly lower than that before treatment（P〈0.01）,and that of the two groups after the treatment had no significant difference（P＆gt;0.05）.Electrocardiogram（ECG）and heart function examination had no abnormal performance. Serum NT-proBNP and h-FABP had significant positive correlation（r=0.629,P〈0.01）,and the correlation was good. Conclusion：Combined detection levels of serum NT-proBNP and h-FABP can early diagnose damage of myocardial cells and heart function in burn patients and can also be used to observe the clinical curative effects.