罗格列酮联合维生素E治疗非酒精性脂肪性肝病的临床研究

Clinical Study on Rosiglitazone Combined with Vitamin E in the Treatment of Nonalcoholic Fatty Liver Disease

目的:探讨罗格列酮联合维生素E治疗非酒精性脂肪性肝病(NAFLD)的临床疗效。方法:将本院进行饮食控制和适当锻炼的90例NAFLD患者随机分为三组,每组30例,分别应用罗格列酮、维生素E、罗格列酮联合维生素E三种方法治疗,疗程为6个月。比较治疗前后各组肝功能指标(ALT、AST、GGT)、血脂水平(TG)、NAFLD超声形态学的改善情况。结果:治疗后三组肝功能、血脂较治疗前均有所改善(P<0.05),其中肝功能(ALT、AST、GGT)改善尤为明显(P<0.01)。治疗后三组肝功能、血脂比较差异均有统计学意义(P<0.01),联合组治疗后肝功能(ALT、AST、GGT)改善优于维生素E组及罗格列酮组(P<0.01),TG改善亦优于其他两组(P<0.05)。维生素E组、罗格列酮组、联合组有效率分别为53.33%,66.67%,90.00%;联合组与罗格列酮组、维生素E组比较,差异均有统计学意义(字2=4.812,P<0.05;字2=9.932,P<0.01)。结论:罗格列酮和维生素E联合治疗NAFLD安全有效,且联合治疗的效果要优于单药治疗。

Objective：To investigate the effect of rosiglitazone combined with vitamin E in the treatment of nonalcoholic fatty liver disease（NAFLD）. Method：90 cases of NAFLD with diet control and exercise in our hospital were randomly divided into three groups,30 cases in each gloup.Three groups were treated with rosiglitazone,vitamin E and rosiglitazone combined with vitamin E separately.The course was 6 months.Liver function indexes（ALT,AST,GGT）,blood lipid levels（TG）,and the improvement situation of NAFLD ultrasound morphology before and after treatment of three groups were compared. Result：The three groups after treatment liver function,blood lipid than before treatment improved（P〈0.05）,and the liver function（ALT,AST,GGT）improvement was obvious（P〈0.01）.The three groups after treatment liver function,blood lipid differences were statistically significant（P〈0.01）,combined liver function group after treatment （ALT,AST,GGT）was better than vitamin E group and rosiglitazone group（P〈0.01）,TG improvement was better than the other two groups（P〈0.05）. Vitamin E group,rosiglitazone group,combined group effective rate were 53.33%,66.67%,90%. Combined group compared with rosiglitazone group,χ2=4.812,P〈0.05;compared with vitamin E, χ2=9.932,P〈0.01. Conclusion：Rosiglitazone combined with vitamin E is safe and effective in the treatment of NAFLD,and combined therapy is better than the single drug therapy.