结核合并糖尿病患者血γ干扰素的检测和意义

Detection and significance of γ-interferon in patients with pulmonary tuberculosis complicated with diabetes

目的研究肺结核合并糖尿病患者血γ干扰素水平检测的临床价值。方法选择32例肺结核合并糖尿病患者作为研究对象,采集外周血检测γ干扰素水平,并与31例单一肺结核患者进行比较,同时观察IFN-γ表达水平与呼吸功能的相关性。结果肺结核合并糖尿病(涂阳/涂阴)组IFN-γ水平明显低于肺结核(涂阳/涂阴)组;两组治疗后1月与治疗前IFN-γ表达水平无显著性,治疗后3月明显低于治疗前。结论肺结核合并糖尿病患者与肺结核患者IFN-γ表达水平各有不同,均随病情的好转而下降。

Objective To study the clinical value of the detection of γ-interferon in patients with pulmonary tuberculosis complicated with diabetes. Methods 32 patients with pulmonary tuberculosis complicated with diabetes were selected as research objects. Their peripheral blood level of interferon γ was detected. At the same time, they were compared with 31 patients pulmonary tuberculosis. Results The level of IFN-γ was obviously lower in the observation group than in the control group. There was no significant difference in IFN- γ 1 month after the treatment and before treatment. The expression of IFN-γ decreased obviously 3 months after the treatment. Conclusion The expression of IFN- γ is different in patients with pulmonary tuberculosis complicated with diabetes and pulmonary tuberculosis only, and it decreases with the improvement of the disease.