摘要
脂肪因子是主要由脂肪组织分泌,对骨代谢具有重要调节作用的蛋白质.脂肪因子种类繁多,包括脂联素、瘦素、趋化素等.不同脂肪因子对骨代谢的影响不尽相同.脂联素、网膜素-1、丝氨酸蛋白酶抑制剂、内脂素可正向调节骨代谢.趋化素、抵抗素对骨代谢具有负向调节作用.瘦素对骨代谢的影响则表现为直接的正向调节作用和间接的负向调节作用.脂肪因子对骨代谢的调节作用可能为骨质疏松的治疗提供新方向.
Adipokines are proteins mainly secreted by adipose tissue.Adipokines play an important role in the regulation of bone metabolism.There are many kinds of adipokines,such as adiponectin,leptin and chemirin.Their effects on bone remodeling vary in different adipokines.Adiponectin,omentin-1,vaspin,visfatin act positively on bone metabolism.Chemirin and resistin act negatively on bone metabolism.Leptin acts both positively and negatively on bone metabolism in direct and indirect ways.The regulation of adipokines on bone remodeling may provide a new direction for the treatment of osteoporosis.
出处
《国际内分泌代谢杂志》
北大核心
2014年第2期95-98,102,共5页
International Journal of Endocrinology and Metabolism
基金
国家自然科学基金资助项目（81300689）
关键词
脂肪因子
骨代谢
Adipokines
Bone metabolism
