摘要
骨质疏松是以骨量减少、骨组织微结构破坏进而导致骨脆性和骨折危险性增加为特征的疾病.激素在骨代谢中具有重要作用,但近年来又发现其他危险因素,如骨硬化蛋白、胶原蛋白基因、G蛋白耦联受体、骨形态发生蛋白、胰岛素样生长因子等.探讨危险因素对骨质疏松形成的影响,将为寻找新的治疗靶点提供方向.
Osteoporosis is characterized by decrease of bone mass and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility and susceptibility to fractures.Hormones play an important role in regulating bone metabolism,however,other risk factors are identified including collagen protein gene,G protein-coupled receptor,bone morphogenetic protein and insulin-like growth factor,etc.Investigating the effects of risk factors on osteoporosis will provide new therapeatic targets.
出处
《国际内分泌代谢杂志》
北大核心
2014年第2期99-102,共4页
International Journal of Endocrinology and Metabolism
关键词
骨质疏松
骨代谢
骨硬化蛋白
G蛋白耦联受体
胶原蛋白基因
Osteoporosis
Bone metabolism
Bone sclerosis
G protein-coupled protein
Collagen protein gene
