结直肠癌术前肠道抗菌准备与否的随机对照研究

The Randomized Controlled Trial on Preoperative Intestinal Antibiotics Preparation in Colorectal Cancer

目的:探讨大肠癌术前口服肠道抗菌素行肠道准备的必要性。方法:选取2011年6月-2012年6月中国医科大学附属第一医院肿瘤外科收治的100例大肠癌患者,采用随机数字表法将其分为试验组和对照组,各50例。试验组术前未口服抗生素行肠道准备,其他治疗同传统方式。对照组术前行传统肠道准备。观察两组患者手术前、后粪便细菌球杆比例及术后并发症。结果:两组患者术前粪便细菌球杆比例均正常,术后大便细菌涂片检查肠道细菌球杆比例均有不同程度变化。试验组患者术后肠道细菌球杆比例失调者5例,程度相对较轻;腹泻2例。对照组术后肠道细菌球杆比例失调者13例,程度相对较重,腹泻8例。试验组术后肠道细菌球杆失调比例明显低于对照组,差异有统计学意义(P<0.05)。但两组患者术后平均住院时间、感染性相关并发症方面比较差异无统计学意义(P>0.05)。结论:大肠癌术前肠道准备不需使用肠道抗菌药物。

Objective：To assess the necessity of preoperative intestinal preparation using oral antibiotic in colorectal cancer. Method：Selection from June 2011 to June 2012,the first hospital affiliated to China medical university at the records of 100 patients with colorectal cancer surgical oncology,using the random number table method divided into trial group and control group,50 cases each. Patients preoperative oral antibiotics do bowel preparation,other treatment with traditional way. Control lines of traditional intestinal preparation. After observing two groups of patients before surgery,fecal bacteria cue proportion and postoperative complications.Result：The preoperative intestinal flora,coccus and bacillus ratio were normal in both groups. There were some variation after surgery. 5 cases occurred disorder of coccus and bacillus ratio in test group,and 2 cases occurred diarrhea. However,13 cases occurred disorder of coccus and bacillus ratio in test group,and 8 cases occurred diarrhea. The difference was significant （P＆lt;0.05）. There was no difference in inpatient time and infectious complications between two groups（P＆gt;0.05）.Conclusion：Preoperative intestinal preparation need not use oral antibiotic in colorectal cancer.