神经节苷脂治疗新生儿缺氧缺血性脑病的临床效果

Clinical Effect of Ganglioside in the Treatment of Neonatal Hypoxic Ischemic Encephalopathy

目的：探讨神经节苷脂治疗新生儿缺氧缺血性脑病的临床治疗效果。方法：选取2011年3月-2013年3月笔者所在医院接收的52例缺氧缺血性脑病的新生儿，按入院顺序随机分为对照组和治疗组，每组26例。两组都进行常规支持及对症治疗，治疗组给予神经节苷脂治疗，对照组则给予胞二磷胆碱治疗。根据病情应用1~3个疗程。结果：治疗组总有效率为88.5%，明显高于对照组的53.8%，两组比较差异有统计学意义（P＆lt;0.05）；两组治疗过程中均未见严重不良反应。结论：神经节苷脂治疗新生儿缺氧缺血性脑病疗效确切，可以在早期使用，能有效的改善患者的临床症状，增加患儿肌力，且无颅内出血，不诱发抽搐，改善意识状况，临床使用中不会引起严重的不良反应，值得推广应用。

Objective：To study the clinical effect of ganglioside in the treatment of neonatal hypoxic ischemia encephalopathy.Method：52 cases patients with newborns received ischemia anoxic encephalopathy from March 2011 to March 2013 in author’s hospital were selected,according to admission order were randomly divided into control group and treatment group,26 cases in each group.All patients of two groups were given regular support and symptomatic treatment, the treatment group was given ganglioside treatment,the control group was given cytidine diphosphate choline.According to the condition two groups were give 1 to 3 period of treatment.Result：The total effective rate of treatment group was 88.5%,were significantly higher than those in the control group（53.8%）,there was significant difference between two groups（P＆lt;0.05）.Two groups were not seen severe adverse reactions in the process of the treatment.Conclusion：The curative effect of ganglioside in the treatment of neonatal hypoxic ischemic encephalopathy is well,can be used in the early days,can effectively improve the patient＆#39;s clinical symptoms,increase children muscle,and has no intracranial hemorrhage,does not induce convulsions,can improve consciousness,does not cause serious adverse reactions in clinical use,is worthy of popularization and application.